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KMID : 0379520170330030205
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한국독성학회지
2017 Volume.33 No. 3 p.205 ~ p.209
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TMEM39A and Human Diseases: A Brief Review
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Tran Quang Don
Park Ji-Soo
Lee Hyun-Ji
Hong Young-Eun
Hong Sun-Taek
Park Sung-Jin
Park Jong-Sun
Kim Seon-Hwan
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Abstract
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Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous of populations. All of these works stop at insufficient information by using gene functioning methods such as: Genome-wide association studies (GWASs) and/or follow-up study. It is the fact that the less understood of TMEM39A actually is the attraction to the scientist in near future. In this review the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology will be described.
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KEYWORD
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Transmembrane proteins family, Multiple sclerosis, Systemic lupus erythematosus, Mitochondria, Mitophagy
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